Human Neurotropic JC Virus and Its Association with Brain Tumors
نویسندگان
چکیده
منابع مشابه
Human Neurotropic JC Virus and Its Association with Brain Tumors
JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progressive Multifocal Leukoencephalopathy (PML). Further, in experimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have suggested the association of JCV with several human tumors most notably malignant brain tumors of childhood, medul...
متن کاملJC virus evolution and its association with human populations.
The ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children. There are at least 14 subtypes of the virus associated with different human populations. Because of its presumed codivergence with humans, JCV has been used as a genetic marker for human evolution and migration. Codivergen...
متن کاملTumor pathogenesis of human neurotropic JC virus in the CNS.
In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus (JCV) and BK virus (BKV), are oncogenic in several animal models, new interest has resurfaced rega...
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چکیده ندارد.
Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome.
B lymphocytes are known as a potential site for latency and reactivation of the human neurotropic polyomavirus, JC virus (JCV). In light of recent studies on the oncogenicity of JCV and the transforming ability of the JCV early protein, T antigen, we investigated the association of JCV with B-cell lymphomas of the central nervous system. Examination of 27 well-characterized clinical specimens b...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 2001
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2001/423875